Abstract
When studying the dose-dependent effect of pirozaline on the activity of papillary muscle contraction of the rat heart, it was found that this alkaloid has a positive inotropic effect on the activity of the papillary muscle contraction of the rat heart at concentrations from 5 μM to 70 μM. Partial reduction of the positive inotropic effect of pirozaline on papillary muscle contractile activity in experiments with nifedipine indicates that the positive inotropic property of this alkaloid partially affects Ca2+L-channels in cardiomyocytes. In the studies carried out in the presence of NiCl2 (10 mM), it was found that the positive inotropic effect of pirozaline on the force of papillary muscle contraction is mainly related to the participation of Na+/Ca2+-exchange.
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